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KMID : 0371320080740010048
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Journal of the Korean Surgical Society
2008 Volume.74 No. 1 p.48 ~ p.53
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The Expression of Vascular Endothelial Growth Factor (VEGF)-C and VEGF-D in Early Gastric Cancer That’s Invaded the Submucosa
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Kim Jung-Koo
Choi Myung-Gyu
Park Won-Sang
Lee Sang-Chul
Lee Dong-Ho
You Young-Kyoung
Ahn Chang-Joon
Park Cho-Hyun
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Abstract
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Purpose: Vascular endothelial growth factor (VEGF)-C and VEGF-D are considered novel growth factors that potentially induce lymphangiogenesis and hyperplasia of lymphatic vessels. The aim of this study was to investigate whether the expressions of VEGF-C and VEGF-D are associated with the clinicophathologic factors, and particularly lymphatic invasion and lymph node metastasis, in early gastric cancers that’s invaded the submucosa.
Methods: Using immunohistochemical staining, we studied the VEGF-C and VEGF-D expressions in the gastric cancer specimens from 83 patients who underwent curative gastrectomy.
Results: The VEGF-C and VEGF-D immunoreactivity was mainly located in the cytoplasm of the tumor cells. There was a positive VEGF-C expression in 27 of 83 cases (32.5%). The VEGF-D positivity rate was lower than the VEGF-C positivity rate. VEGF-D was positive in 20 of 83 cases (24.0%). A VEGF-C positive expression was associated with lymphatic invasion (P=0.018) and lymph node metastasis (P=0.001). However, the expression of VEGF-D had no correlation with any of the clinicopathologic factors, including lymphatic invasion and lymph node metastasis.
Conclusion: The VEGF-C expression may have a role in lymph node metastasis of gastric cancer cells. The VEGF-C expression in tumor specimens may be a reliable marker for lymph node metastasis of early gastric cancer that’s invaded the submucosa. (J Korean Surg Soc 2008;74:48-53)
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KEYWORD
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Early gastric cancer, VEGF-C, VEGF-D, Lymph node metastasis
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